T-TIME Study Results Available Now

Results are now available for the T-TIME study which the NECTAR team were a part of here in Newcastle.

The purpose of this study was to determine the safety and efficacy of reduced doses (10 mg and 20 mg) of intra-coronary alteplase compared with placebo as an adjunct to PCI in reducing MVO and its consequences in high risk patients with STEMI.

The Study team at NHS Greater Glasgow and Clyde and the University of Glasgow who sponsored and lead the trial concluded that among patients with acute STEMI presenting within 6 hours of symptoms, adjunctive low-dose intracoronary alteplase given during the primary percutaneous intervention did not reduce microvascular obstruction. The study findings do not support this treatment.

An abstract of the trial results can be found here