Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation (AVATAR-AF)

Sponsor: Imperial College London Identifier:  NCT02459574


A streamlined AF ablation procedure done without PV mapping as a day case is more effective than anti-arrhythmic drugs at reducing all hospital episodes for recurrent atrial fibrillation.

Condition: Heart Failure Recurrent Atrial Fibrillation


Procedure: AVATAR-AF ablation
Drug: Anti-Arrhythmic therapy


Conventional AF ablation
Detailed Description:

AVATAR-AF is a multicentre, randomised controlled study comparing a streamlined AVATAR-protocol ablation procedure to anti-arrhythmic therapy in patients with documented paroxysmal Atrial Fibrillation who are considered to be failing current strategy for AF. A secondary control arm will also compare the AVATAR-protocol to conventional AF ablation. 300 patients who are on no prior anti-arrhythmic, ‘pill-in-pocket’ or taking regular anti-arrhythmics will be randomised in a 1:1:1 manner to a treatment strategy of either AVATAR-protocol ablation, anti-arrhythmic therapy or conventional AF ablation and followed-up for 1 year.

Visit the Imperial College London’s website trial page <a style="color: #3366ff;" here